Taught by Professor John Guttag, this MIT course provides an Introduction to Computer Science and Programming. It covers "introductory computer science methods and topics," and "all programming assignments use Python."
You can watch all 26 lectures above, or find them on YouTube. A syllabus for the course and related materials can be found on MIT's web site. The optional textbook used in the course is Introduction to Computation and Programming Using Python.
For anyone interested in a course more squarely focused on Python itself, see: Learn Python: A Free Online Course from Google.
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