E. chroÂmi, a short film about a unique colÂlabÂoÂraÂtion between designÂers and biolÂoÂgists has won the best docÂuÂmenÂtary award at Bio:Fiction, the world’s first synÂthetÂic biolÂoÂgy film fesÂtiÂval, held earÂliÂer this month in VienÂna.
E. chroÂmi tells the stoÂry of a project unitÂing designÂers AlexanÂdra Daisy GinsÂberg and James King with a team of underÂgradÂuÂate biolÂoÂgy stuÂdents at CamÂbridge UniÂverÂsiÂty. Using genes from existÂing organÂisms, the team designed cusÂtom DNA sequences, called BioÂBricks, and insertÂed them into E. coli bacteria.The new E. coli—dubbed “E. chromi”—were proÂgrammed to express a rainÂbow of colÂors when exposed to varÂiÂous chemÂiÂcals.
GinsÂberg and King helped the young biolÂoÂgists dream up a variÂety of posÂsiÂble appliÂcaÂtions for the invention.For examÂple, E. chroÂmi could be used to test the safeÂty of drinkÂing water–turning red if a toxÂin is present, green if it’s okay. Or it might be used as an earÂly warnÂing sysÂtem for disÂease: a perÂson would ingest some yogurt conÂtainÂing E. chroÂmi, then watch out for tell-tale colÂors at the othÂer end of the digesÂtive process.
The E. chroÂmi team was awardÂed the grand prize at the 2009 InterÂnaÂtionÂal GenetÂiÂcalÂly EngiÂneered Machine (iGEM) comÂpeÂtiÂtion at the MassÂaÂchuÂsetts InstiÂtute of TechÂnolÂoÂgy. For more films on synÂthetÂic biolÂoÂgy, see the Bio:Fiction webÂsite.